تأثیر روش‌های تمرینی مختلف بر BDNF سرم، عملکرد جسمانی، ناتوانی عملکردی و کیفیت زندگی افراد مبتلا به مولتیپل اسکلروزیس

Objective: The present research aimed to investigate the effect of different training methods on serum BDNF, physical performance, functional disability and quality of life in people with multiple sclerosis. &nbsp; Materials and Methods: The present research type was semi-experimental and applied. For this purpose, inactive female patients with MS were examined and chosen by a neurologist through EDSS test. Then, 52 patients of the intended subjects were then selected and randomly divided into four groups of ten members (Control, Pilates training, water aerobics, and massage). The variables were evaluated as pre-test and post-test before and after 12 weeks to investigate training interventions. &nbsp; Results: The results showed a significant difference in all variables between different groups (p < 0.005). Also, Bonferroni post hoc test showed a significant difference between training and control groups in the variables of BDNF, quality of life, Oswestry balance and disability (p< 0.005). But no difference was observed between Pilates and massage groups (p>0.005). In addition, the results indicated a reduction in the degree of pain in water aerobics group and a significant difference between water aerobics, Pilates and massage groups and the control group (p<0.005). But no difference was observed between other groups (p>0.005). Also, the variable of EDSS level was most improved in water aerobics group. This caused a significant difference between this group and the control, Pilates and massage groups (p<0.005). &nbsp; Conclusion: It appeared water aerobics is a good training strategy to improve MS patients as compared to other training methods.